Plasminogen Activator Inhibitor 1 (PAI-1) 4G/5G Polymorphism

TEST: 500309
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CPT: 81400
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Synonyms

  • PAI-1 4G/5G Polymorphism
  • Plasminogen Activator Inhibitor (PAI-1), Gene Polymorphism

Special Instructions

Informed consent is required for New York patients.

Expected Turnaround Time

5 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Procedures for Hemostasis and Thrombosis: A Clinical Test Compendium

    Specimen Requirements

    Specimen

    Whole blood

    Volume

    1 mL

    Container

    Lavender-top (EDTA) tube or yellow-top (ACD) tube

    Storage Instructions

    Maintain specimen at room temperature. Stable at room temperature or refrigerated for eight days.

    Test Details

    Limitations

    This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Results of this test are for investigational purposes only. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

    Methodology

    Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technologies

    Additional Information

    Deep vein thrombosis (DVT) and coronary artery disease (CAD) are associated with increased PAI-1 levels. Elevated PAI-1 levels may help predict risk of reinfarction in survivors of myocardial infarction, particularly in young individuals. PAI-1 levels tend to be lower in individuals with 4G/5G or 5G/5G genotype compared to a 4G/4G genotype.

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    500309 PAI-1 Gene Polymorphism 52757-2 500310 PAI-1 Locus 4G/5G Polymorphism N/A
    500309 PAI-1 Gene Polymorphism 52757-2 500311 Results 52757-2
    500309 PAI-1 Gene Polymorphism 52757-2 500312 Interpretation N/A
    500309 PAI-1 Gene Polymorphism 52757-2 500313 Comments 77202-0