Venous Thrombosis Profile (Esoterix)
Test Includes
Activated partial thromboplastin time (aPTT); anticardiolipin antibodies IgG, IgM; antithrombin activity; β2-glycoprotein I, IgA, IgG, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; dilute Russell's viper venom time (dRVVT) screen seconds; factor II gene mutation; factor VIII activity; hexagonal phospholipid neutralization; homocysteine; protein C activity (chromogenic); protein C resistance with factor V deficiency; protein S antigen, free
Special Instructions
Informed consent is required for New York patients. Test will reflex to Factor V Leiden Gene Mutation if APCR is abnormal. If abnormal, aPTT will reflex to Immediate aPTT Mixing Studies. If reflex test is performed, concomitant CPT codes/charges will apply.
Expected Turnaround Time
5 - 14 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Specimen Requirements
Specimen
Serum, plasma, and whole blood
Volume
Three 2-mL platelet-poor, frozen citrated plasma tubes, 5 mL whole blood, and 2 mL frozen serum
Container
Gel-barrier tube or red-top tube, lavender-top (EDTA) tube or yellow-top (ACD) tube, and blue-top (sodium citrate) tube
Collection
Plasma must be separated from cells within 45 minutes of venipuncture. Plasma must be centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed. Allow gel-barrier tube or red-top tube to clot, centrifuge, and remove serum from cells within one hour. Send serum in plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze serum and plasma. Maintain whole blood at room temperature; stable for seven days.
Causes for Rejection
Noncitrated plasma; gross hemolysis; fibrin clot; clotted samples if adequate DNA not obtained
Test Details
Methodology
See individual tests.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 501790 | Venous Thrombosis Profile | 501701 | Homocysteine | umol/L | 13965-9 | |
| 501790 | Venous Thrombosis Profile | 500666 | Factor VIII Activity | % | 3209-4 | |
| 501790 | Venous Thrombosis Profile | 500573 | Antithrombin Activity, Plasma | % | 27811-9 | |
| 501790 | Venous Thrombosis Profile | 500464 | Prt C Activity (Chromogenic) | % | 27818-4 | |
| 501790 | Venous Thrombosis Profile | 500618 | Protein S Antigen, Free | % | 27821-8 | |
| 501790 | Venous Thrombosis Profile | 500513 | APTT | sec | 14979-9 | |
| 501790 | Venous Thrombosis Profile | 500363 | APTT 1:1 NP | sec | 5946-9 | |
| 501790 | Venous Thrombosis Profile | 500364 | APTT 1:1 Saline | Sec | 43734-3 | |
| 501790 | Venous Thrombosis Profile | 502038 | LAC Interpretation | 77202-0 | ||
| 501790 | Venous Thrombosis Profile | 501172 | Act. Prt C Resist w/FV Defic. | ratio | 13590-5 | |
| 501790 | Venous Thrombosis Profile | 501549 | DRVVT Screen Seconds | sec | 6303-2 | |
| 501790 | Venous Thrombosis Profile | 501548 | DRVVT Confirm Seconds | sec | 57838-5 | |
| 501790 | Venous Thrombosis Profile | 500585 | DRVVT Ratio | ratio | 50410-0 | |
| 501790 | Venous Thrombosis Profile | 500569 | Hexagonal Phospholipid Neutral | sec | 3282-1 | |
| 501790 | Venous Thrombosis Profile | 500575 | Anticardiolipin Ab, IgG | GPL | 3181-5 | |
| 501790 | Venous Thrombosis Profile | 500571 | Anticardiolipin Ab, IgM | MPL | 3182-3 | |
| 501790 | Venous Thrombosis Profile | 500589 | Beta-2 Glycoprotein I, IgG | SGU | 16135-6 | |
| 501790 | Venous Thrombosis Profile | 500593 | Beta-2 Glycoprotein I, IgM | SMU | 16136-4 | |
| 501790 | Venous Thrombosis Profile | 500591 | Beta-2 Glycoprotein I, IgA | SAU | 21108-6 | |
| 501790 | Venous Thrombosis Profile | 500583 | Factor II Gene Mutation Result | 24476-4 | ||
| 501790 | Venous Thrombosis Profile | 500624 | Interpretation: | 51968-6 | ||
| 501790 | Venous Thrombosis Profile | 500625 | Methodology: | 49549-9 | ||
| 501790 | Venous Thrombosis Profile | 500626 | Comments: | 77202-0 |
| Reflex Table for Act. Prt C Resist w/FV Defic. | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 500586 | Factor V Leiden | 500587 | Factor V Leiden Result | 21667-1 | |
| Reflex Table for Act. Prt C Resist w/FV Defic. | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 500586 | Factor V Leiden | 500627 | Interpretation: | 51968-6 | |
| Reflex Table for Act. Prt C Resist w/FV Defic. | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 500586 | Factor V Leiden | 500628 | Methodology: | 49549-9 | |
| Reflex Table for Act. Prt C Resist w/FV Defic. | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 500586 | Factor V Leiden | 500629 | Comments: | 77202-0 | |
| Reflex Table for Act. Prt C Resist w/FV Defic. | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 500586 | Factor V Leiden | 500811 | Factor V Leiden | N/A | |